Research backs parasite-HIV link

NotAIDS! has been saying for some time that many of the same immunosuppresive symptoms attributed to HIV can be a misdiagnosis of intestinal or other parasite infections.

Research has been published here that shows identical proteins and surface proteins are expressed by various parasites as by HIV, such as p24, gp160.

Not long ago, there was a splashy announcement in the mainstream press that "HIV lives in the gut" and hides out in the lymphatic tissue.  Interesting, since intestinal parasites hang out in the same neighborhood.

How coincidental that Irritable Bowel Syndrome affected a great many gay men in the 1970s, but this "syndrome" - a eupheism for intestinal parasites - disappeared suddenly around 1981, and was replaced with something called GRID - Gay Related Immune Deficiency -, ultimately becoming known as AIDS.

To fit the HIV/AIDS model, any disease occuring in the presence of a silly little antibody to an even sillier little retrovirus named unimaginitively,  Human Immunodeficiency Virus, is "coinfection." 

Keeping this in mind, divert for a moment and ask yourself, when you have the flu, or  a cold, is it said that you are "coinfected" with mononucleosis or meningitis - which you had when you were in college and for which you still have antibodies?

As far as the HIV/AIDS model is concerned, it is reported that "coinfection" with HIV and the  parasite, cryptospordium, is a leading cause of mortality from AIDS. 

What a surprise.   

Now read the following Author's Summary of just-completed research into the connection between intestinal parasites and, not just the progression to AIDS, but to the prevalence of AIDS in regions where parasitic infections are endemic due to an shameful lack of water purification and sanitation systems.

 Please note that the AIDS industry is busy sending millions of dollars to these regions for pharmaceutical products, rather than building much more cost-efficient solutions, like sewage systems and drinking water filtration facilities. 

The other question you need to ask, is whether there is even a remote possibility that without HIV, a long-term parasite infection will cause AIDS - meaning a syndrome of immune deficiency as indicated by a plethora of infections which normally the body would defeat.

If there is this possibility, then AIDS researchers all over the world may want to think about switching tracks, from the glamorous celebrity that is an insignficant retrovirus, to a field definitely with more ick-factor, and less star-appeal

- The Editor


 

Author Summary

To test the hypothesis that infection with helmiths may increase host susceptibility to infection with HIV-1, we quantified the amount of a clade C simian-human immunodeficiency virus needed to infect rhesus macaques that had acute Schistosoma mansoni infections.

Compared to control animals exposed to virus alone, monkeys with schistosomiasis required exposure to 17-fold lower levels of virus to become infected. The schistosome-infected monkeys also had significantly higher levels of initial virus replication and loss of a certain subset of memory T cells, both predictors of a more rapid progression to immune dysfunction.

These results suggest that worm infections may increase the risk of becoming infected with HIV-1 among individuals with viral exposures.

Furthermore, they support the idea that control programs for schistosomiasis and perhaps other parasitic worm infections may also be useful in helping to reduce the spread of HIV/AIDS in developing countries where helminths are endemic.

Conclusions/Significance

Our data provide the first direct evidence that acute schistosomiasis significantly increases the risk of de novo AIDS virus acquisition, and the magnitude of the effect suggests that control of helminth infections may be a useful public health intervention to help decrease the spread of HIV-1.

Citation: Chenine A-L, Shai-Kobiler E, Steele LN, Ong H, Augostini P, et al. (2008) Acute Schistosoma mansoni Infection Increases Susceptibility to Systemic SHIV Clade C Infection in Rhesus Macaques after Mucosal Virus Exposure. PLoS Negl Trop Dis 2(7): e265. doi:10.1371/journal.pntd.0000265

 

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