NotAIDS! Investigative Report

May 8, 2007

   The most absurd development thus far coming out of the AIDS industry is a new syndrome dubbed IRIS, an acronym for Immune Reconstitution Inflammatory Syndrome.¹ 

    IRIS is a new syndrome, caused by the drugs used to treat another syndrome, the famously named Acquired Immune Deficiency Syndrome, purported all these years to be caused by yet another fabrication, the 'Human Immuno-deficiency Virus' or HIV.

    Creatively devising a way of identifying what is rather more than likely the deleterious side effects of antiretroviral (ARV) therapy (ART), the self-titled AIDS research scientists have outdone themselves.

    They have not-so-cleverly deluded themselves into believing that the drugs improved the lives of the victims so well that they are now falling ill and dead because their immune system is doing too well. It seems the end point for evaluating the efficacy of their AIDS drugs is death: the immune system's ultimate victory. No matter that the illnesses are the very same on the AIDS list.

"Resulting clinical manifestations of this syndrome are diverse and depend on the infectious or noninfectious agent involved. "These manifestations include mycobacterial- induced lymphadenitis, paradoxical tuberculosis reactions, worsening of progressive multifocal leukoencephalopathy (PML)... cryptococcosis and Pneumocystis jirovecii pneumonia (PCP), Cytomegalovirus (CMV) retinitis, shingles, and viral hepatitis, as well as noninfectious phenomena."

    How better to mask the persistently adverse events caused by ART than to blame them on the victim's own "robust" immune response. In the bewildering report published yesterday, May 8, 2007, by the widely read and respected journal, AIDS Research and Therapy, the authors make this most ludicrous claim, based on their review of over one-hundred journal articles describing often deadly medical consequences suffered by victims of AIDS science.

"After initiation of ART, opportunistic infections (OI) and other HIV-related events still occur secondary to a delayed recovery of adequate immunity. Some patients initiating ART experience unique symptoms during immune system recovery. In these patients, clinical deterioration occurs despite increased CD4+ Tlymphocyte counts and decreased plasma HIV-1 viral loads."

If the AIDS industry were any less predictable, this may sound like an admission of their failed paradigm, one that does not need repeating. Witness instead the birth of a new syndrome born out of the hubris of a mad science:

"Because clinical deterioration occurs during immune recovery, this phenomenon has been described as immune restoration disease (IRD), immune reconstitution syndrome (IRS), and paradoxical reactions. Given the role of the host inflammatory response in this syndrome, the term immune reconstitution inflammatory syndrome (IRIS) has been proposed² and has become the most widely used and accepted term to describe the clinical entity."¹

   Over seven years ago, the January 28, 2000 issue of the journal, AIDS contained a report³ on one of the precious few studies (the first of only two such published reports The Editor has been able to locate) comparing AIDS treatment victims to those individuals who declined AIDS medications, or in the research vernacular, 'highly active antiretroviral therapy-treated and antiretroviral-naïve' study participants.

"We investigated the hypothesis that different immune profiles would be present in HAART-treated and in antiretroviral-naïve individuals with undetectable viraemia and comparable viral loads, CD4 counts, disease duration, and clinical stage. Our results show that immune responses are potent in antiretroviral-naïve but significantly reduced in HAART-treated patients with undetectable viraemia (<500 copies/ml). The data stemming from this preliminary cross-sectional study demonstrate that a potent immune response is associated with containment of HIV replication in drugs-naïve individuals."

This astonishing observation, put in layperson's terms, means that the unfortunate victims of their ARV toting medical caregivers are damaging their immune systems as a direct result of the administered drugs. The report's authors concluded,

"HIV-specific potent immune responses have been associated with control over HIV replication and disease progression in a fortunate group of HIV-infected individuals not undergoing antiretroviral therapy."

Apparently, this group's good fortune is a serendipitous consequence of declining antiretroviral drugs.

Different observations suggest that lack of disease progression, in the absence of therapy, is correlated with potent immune functions. Thus in HIV-infected patients in whom HIV viral load is controlled without therapy: (1) preserved T-cell function correlates with stable CD4 counts [16,17]; and (2) disease-free survival correlates with gag-specific cytotoxic T-lymphocyte activity [28]. Robust HIV-specific cytotoxic T lymphocytes (CTL) activity toward other epitopes [29,30] is detected in these patients as well."

Fast-forward to the present day's research, and the damage cited in the January 28, 2000 article has been flipped over to now mean that the treated study participants have had the 'robust' immune response, so much so that they are actually getting sick and dying.

    Did I slip through a wormhole or is the absurdity inherent in this twisted logic obvious to anyone else? All of this is really quite sad despite the attempt at wittiness. That the medical establishment has known for at least seven years the damage caused by these drugs is unforgiveable.

   Seven years ago, in a point-counterpoint discussion of the Clerici paper, W. Fred Shaw, then editor of The Fauci Files - a trendsetting web log, or blog - interpreted the work of eminent scientists such as Nobelist Rolf Zinkernagel to mean that ART

"increases blood CD4 T-cells -- not by creating NEW CD4 T-cells, but rather by inducing the redistribution of the CD4 cells that are ALREADY present in the lymphoid tissues (thus, the lab CD4 measure becomes a superstitious treatment artifact of no true value)."

   Interestingly, seven years later, today's article on Western Medicine's newest nightmare, IRIS, includes one enlightened nugget, and it is oddly reminiscent of Mr. Shaw's conculusion so many years ago:

"An alternative immunological mechanism may involve qualitative changes in lymphocyte function or lymphocyte phenotypic expression. For instance, following ART an increase in memory CD4 cell types is observed possibly as a result of redistribution from peripheral lymphoid tissue."

##

1.. "Immune reconstitution inflammatory syndrome (IRIS): Review of common infectious manifestations and treatment options," AIDS Research and Therapy, 8 May 2007, by David M Murdoch *1,3, Willem DF Venter *2, Annelies Van Rie3, and Charles Feldman *4

3. Different immunologic profiles characterize HIV infection in highly active antiretroviral therapy-treated and antiretroviral-naïve patients with undetectable viraemia [BASIC SCIENCE] Clerici, Marioa; Seminari, Elenab; Suter, Fredyc; Castelli, Francescod; Pan, Angeloe; Biasin, Maraa; Colombo, Fulviaa; Trabattoni, Dariaa; Maggiolo, Francoc; Carosi, Giampierod; Maserati, Renatob; for the Master Group From the aCattedra di Immunologia, Universita' degli Studi di Milano, Padiglione L.I.T.A., Ospedale L. Sacco, Milan, the bClinica Malattie Infettive, IRCCS San Matteo, Universita' di Pavia, Pavia, the cMalattie Infettive, Ospedale di Circolo, Busto Arsizio, Varese, the dClinica Malattie Infettive e Tropicali, Spedali Civili, Universita' di Brescia, Brescia and the eMalattie Infettive, Cremona, Italy. Sponsorship: Supported by grants from Istituto Superiore di Sanita' `I Programma Nazionale di Ricerca sull' AIDS 1997'. Correspondence to Dr Mario Clerici, Cattedra di Immunologia, Universitá degli Studi di Milano, Via Venezian, 1, 20133 Milan, Italy. Tel: +390238210354; fax: +390238210350; e-mail: mago@mailserver.unimi.it

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