AIDS news & views

ONCOLOGY: Answers to age-old questions surrounding fat cell cancer Myxoid round cell liposarcoma (MRCLS) is a cancerous tumor that typically arises in deep fat tissues of the limbs or abdomen. It was shown almost 20 years ago to be characterized by a chromosomal change that generates a fusion protein known as TLS:CHOP...

Background: Several lines of evidence suggest that retinoids (retinol-ROL or vitamin A, and its active metabolites, retinoic acids-RAs) play important pathogenic roles in HIV infection and combination antiretroviral therapy (cART)-related events. We previously reported that antiretrovirals alter RAs synthesis in vitro. We hypothesised that in vivo serum retinoid concentrations are affected by both cART and HIV infection. This might explain several clinical and laboratory abnormalities reported in HIV-infected patients receiving cART. Methods: The effects of optimal cART and chronic HIV on serum retinoids were firstly assessed longitudinally in 10 HIV-infected adults (group1=G1): twice while on optimal cART (first, during long-term and second, during short term cART) and twice during 2 cART interruptions when HIV viral load (VL) was detectable. Retinoid concentrations during optimal long term cART in G1 were compared with cross-sectional results from12 patients (G2) with suboptimal cART (detectable VL) and from 28 healthy adults (G3). Serum retinoids were measured by HPLC with ultraviolet detection. Retinoid concentrations were correlated with VL, CD4+ T- cell count and percentages, CD8+38+ fluorescence, triglycerides, cholesterol and C-peptide serum levels. Results: During optimal cART, G1 participants had drastically reduced RAs (0.5 +/- 0.3 micrograms/dL; P<0.01) but the highest ROL (82 +/-3.0 micrograms/dL) concentrations. During cART interruptions in these patients, RAs slightly increased whereas ROL levels diminished significantly (P<0.05). G3 had the highest RAs levels (7.2 +/-1.1 micrograms/dL) and serum ROL comparable to values in North Americans. Serum ROL was decreased in G2 (37.7 +/- 3.2 micrograms/dL; P<0.01). No correlations were noted between RA and ROL levels or between retinoid concentrations and CD4+ T- cell count, CD8+38+ fluorescence, VL. ROL correlated with triglycerides and cholesterol in G1 (rs =0.8; P=0.01). Conclusions: Serum RAs levels are significantly diminished by cART, whereas ROL concentrations significantly decreased during uncontrolled HIV infection but augmented with optimal cART. These alterations in retinoid concentrations may affect the expression of retinoid-responsive genes involved in metabolic, hormonal and immune processes and be responsible for some adverse events observed in HIV-infected persons treated with antiretrovirals. Further studies should assess concomitant serum and intracellular retinoid levels in different clinical situations in larger, homogenous populations.

Background: Several lines of evidence suggest that retinoids (retinol-ROL or vitamin A, and its active metabolites, retinoic acids-RAs) play important pathogenic roles in HIV infection and combination antiretroviral therapy (cART)-related events. We previously reported that antiretrovirals alter RAs synthesis in vitro. We hypothesised that in vivo serum retinoid concentrations are affected by both cART and HIV infection. This might explain several clinical and laboratory abnormalities reported in HIV-infected patients receiving cART. Methods: The effects of optimal cART and chronic HIV on serum retinoids were firstly assessed longitudinally in 10 HIV-infected adults (group1=G1): twice while on optimal cART (first, during long-term and second, during short term cART) and twice during 2 cART interruptions when HIV viral load (VL) was detectable. Retinoid concentrations during optimal long term cART in G1 were compared with cross-sectional results from12 patients (G2) with suboptimal cART (detectable VL) and from 28 healthy adults (G3). Serum retinoids were measured by HPLC with ultraviolet detection. Retinoid concentrations were correlated with VL, CD4+ T- cell count and percentages, CD8+38+ fluorescence, triglycerides, cholesterol and C-peptide serum levels. Results: During optimal cART, G1 participants had drastically reduced RAs (0.5 +/- 0.3 micrograms/dL; P<0.01) but the highest ROL (82 +/-3.0 micrograms/dL) concentrations. During cART interruptions in these patients, RAs slightly increased whereas ROL levels diminished significantly (P<0.05). G3 had the highest RAs levels (7.2 +/-1.1 micrograms/dL) and serum ROL comparable to values in North Americans. Serum ROL was decreased in G2 (37.7 +/- 3.2 micrograms/dL; P<0.01). No correlations were noted between RA and ROL levels or between retinoid concentrations and CD4+ T- cell count, CD8+38+ fluorescence, VL. ROL correlated with triglycerides and cholesterol in G1 (rs =0.8; P=0.01). Conclusions: Serum RAs levels are significantly diminished by cART, whereas ROL concentrations significantly decreased during uncontrolled HIV infection but augmented with optimal cART. These alterations in retinoid concentrations may affect the expression of retinoid-responsive genes involved in metabolic, hormonal and immune processes and be responsible for some adverse events observed in HIV-infected persons treated with antiretrovirals. Further studies should assess concomitant serum and intracellular retinoid levels in different clinical situations in larger, homogenous populations.

Background: Several lines of evidence suggest that retinoids (retinol-ROL or vitamin A, and its active metabolites, retinoic acids-RAs) play important pathogenic roles in HIV infection and combination antiretroviral therapy (cART)-related events. We previously reported that antiretrovirals alter RAs synthesis in vitro. We hypothesised that in vivo serum retinoid concentrations are affected by both cART and HIV infection. This might explain several clinical and laboratory abnormalities reported in HIV-infected patients receiving cART. Methods: The effects of optimal cART and chronic HIV on serum retinoids were firstly assessed longitudinally in 10 HIV-infected adults (group1=G1): twice while on optimal cART (first, during long-term and second, during short term cART) and twice during 2 cART interruptions when HIV viral load (VL) was detectable. Retinoid concentrations during optimal long term cART in G1 were compared with cross-sectional results from12 patients (G2) with suboptimal cART (detectable VL) and from 28 healthy adults (G3). Serum retinoids were measured by HPLC with ultraviolet detection. Retinoid concentrations were correlated with VL, CD4+ T- cell count and percentages, CD8+38+ fluorescence, triglycerides, cholesterol and C-peptide serum levels. Results: During optimal cART, G1 participants had drastically reduced RAs (0.5 +/- 0.3 micrograms/dL; P<0.01) but the highest ROL (82 +/-3.0 micrograms/dL) concentrations. During cART interruptions in these patients, RAs slightly increased whereas ROL levels diminished significantly (P<0.05). G3 had the highest RAs levels (7.2 +/-1.1 micrograms/dL) and serum ROL comparable to values in North Americans. Serum ROL was decreased in G2 (37.7 +/- 3.2 micrograms/dL; P<0.01). No correlations were noted between RA and ROL levels or between retinoid concentrations and CD4+ T- cell count, CD8+38+ fluorescence, VL. ROL correlated with triglycerides and cholesterol in G1 (rs =0.8; P=0.01). Conclusions: Serum RAs levels are significantly diminished by cART, whereas ROL concentrations significantly decreased during uncontrolled HIV infection but augmented with optimal cART. These alterations in retinoid concentrations may affect the expression of retinoid-responsive genes involved in metabolic, hormonal and immune processes and be responsible for some adverse events observed in HIV-infected persons treated with antiretrovirals. Further studies should assess concomitant serum and intracellular retinoid levels in different clinical situations in larger, homogenous populations.

Health authorities in South Africa have recalled more than a million condoms that were handed out in the lead up to the African National Congress centenary celebrations...

Using a combination of evolutionary biology and virology, scientists at Fred Hutchinson Cancer Research Center have traced the birth of the ability of some HIV-related viruses to defeat a newly discovered cellular-defense system in primates. The research, led by Michael Emerman, Ph.D., a member of the Hutchinson Center's Human Biology and Basic Sciences Division, and Harmit Malik, Ph.D...

HIV-positive mothers can protected their babies from becoming infected with the virus if they take antiretroviral drugs during pregnancy. However, even though these drugs prevent transmitting the disease to the child, they could potentially cause birth defects like cleft lip and palate...

Radiation therapy with or without chemotherapy is less effective for patients with HIV when compared to the recurrence and overall survival rates in patients who do not have HIV, according to a study presented at the Multidisciplinary Head and Neck Cancer Symposium, sponsored by AHNS, ASCO, ASTRO and SNM. Treating head and neck cancer in HIV-positive patients is a challenge for oncologists...

If there was no HIV/AIDS, South Africa would have 4.4 million more people than today, the size of a major city. This significant slow-down in population growth is causing a slow down in economic growth and resulting in social ills, researchers warn.

A saliva test used to diagnose the human immunodeficiency virus (HIV), is comparable in accuracy to the traditional blood test, according to a new study led by the Research Institute of the McGill University Health Centre (RI-MUHC) and McGill University...

This is a brief summary of a consultation sponsored by DHAP in collaboration with the Health Resources Services Administration (HRSA), HIV/AIDS Bureau (HAB), sponsored a Consultation on Monitoring and Use of Laboratory Data Reported to HIV Surveillance, March 9-10, 2011, in Atlanta, Georgia. The purpose of the consultation was to explore science, program, and ethical considerations for collection and use of laboratory indicators in HIV surveillance for public health action and monitoring.

A spoonful of medicine goes down a lot easier if there is a dog or cat around. Having pets is helpful for women living with HIV/AIDS and managing their chronic illness, according to a new study from the Frances Payne Bolton School of Nursing at Case Western Reserve University. "We think this finding about pets can apply to women managing other chronic illnesses," said Allison R...

Recent surveillance data show that young persons in the United States are markedly affected by HIV. The 2009 HIV Surveillance Report, published by the Cen¬ters for Disease Control and Prevention (CDC), revealed that the estimated number and estimated rate of annual diagnoses of HIV infection remained stable from 2006 through 2009 in the 40 states with mature confidential name-based HIV infection reporting. However, during this period, the estimated rates of diagnoses of HIV infection among persons aged 15– 19 years increased 25%, and that among persons aged 20–24 years increased 31%.

While global attention to HIV/AIDS remains strong, a lack of focus on prevention strategies is stonewalling health experts in many developing nations, specifically in the Caribbean...

According to a study published in the current issue of the journal Cancer Prevention Research, aspirin should be assessed for its ability to prevent cervical cancer developing in women infected with HIV. Aspirin has the potential to provide considerable benefit for women in Africa, the Caribbean and Latin America, regions where death rates from cervical cancer are extremely high...

Research conducted by NewYork-Presbyterian Hospital/Weill Cornell Medical Center global health investigators and cancer specialists in New York, Qatar and Haiti suggests that aspirin should be evaluated for its ability to prevent development of cervical cancer in HIV-infected women...

Recently, it has been shown that human ejaculate enhances human immunodeficiency virus 1 (HIV-1) infectivity. Enhancement of infectivity is conceived to be mediated by amyloid filaments from peptides that are proteolytically released from prostatic acid phosphatase (PAP), termed Semen-derived Enhancer of Virus Infection (SEVI). The aim of this study was to test the range of HIV-1 infectivity enhancing properties of a large number of individual semen samples (n=47) in a TZM-bl reporter cell HIV infection system. We find that semen overall increased infectivity to 156% of the control experiment without semen, albeit with great inter- and intraindividual variability (range -53%-363%). Using transmission electron microscopy, we provide evidence for SEVI fibrils in fresh human semen for the first time. Moreover, we confirm that the infectivity enhancing property can be inhibited by the major green tea ingredient epigallocatechin-3-gallate (EGCG) at non-toxic concentrations. The median inhibition of infection by treatment with 0.4 mM EGCG was 70.6% (p<0.0001) in our cohort. Yet, there were substantial variations of inhibition and in a minority of samples, infectivity enhancement was not inhibited by EGCG treatment at all. Thus, topical application of EGCG may be a feasible additional measure to prevent the sexual transmission of HIV. However, the reasons for the variability in the efficacy of the abrogation of semen-mediated enhancement of HIV-1 infectivity and EGCG efficacy have to be elucidated before therapeutic trials can be conducted.

CDC is now into its third year of the Act Against AIDS (AAA) campaign, and we want to take this opportunity to share with you some of the highlights of the first 2 years and the many exciting activities that are underway.

1. High Doses of Vitamin D Provide No Benefit to Patients with Severe COPD Chronic obstructive pulmonary disease (COPD) is one of the top 10 leading causes of morbidity and mortality in the United States. Vitamin D deficiency is present in 60 percent to 75 percent of patients with severe COPD...

1. High Doses of Vitamin D Provide No Benefit to Patients with Severe COPD Chronic obstructive pulmonary disease (COPD) is one of the top 10 leading causes of morbidity and mortality in the United States. Vitamin D deficiency is present in 60 percent to 75 percent of patients with severe COPD...